Sperm DNA Fragmentation Testing

Part of the genetic material (DNA) required to make an embryo is provided by a single sperm, while the remaining portion is derived from the female egg. The probability of obtaining a healthy pregnancy drops if the sperm’s DNA is significantly fragmentary. Oxidative stress is the predominant factor responsible for sperm DNA fragmentation.

Stem cells with a high DNA fragmentation index can be improved with dietary and lifestyle modifications. DNA damage to sperm can be caused by a variety of factors, including high testicular temperature, drug and alcohol abuse, smoking, and poor diet.

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What is a sperm DNA fragmentation test?

Sperm DNA fragmentation is an advanced test used to determine the damage or “fragmentation” of sperm. While sperm might show good results when looking at motility and volume during a semen analysis, a DNA fragmentation test for sperm may reveal other damage which may negatively impact the sperm’s ability to fertilise an egg. Taking a male fertility assessment can uncover certain issues and offer guidance for what next steps you should take.

What causes sperm DNA fragmentation?

Sperm DNA fragmentation is linked to intrinsic factors like oxidative stress, which is an imbalance of certain molecules in your body. This can be provoked by underlying health issues or extrinsic lifestyle factors, such as smoking, environmental pollutants, or excessive heat exposure.

Additionally, sperm DNA fragmentation may be triggered by testicular mechanisms like abortive apoptosis, which impacts natural and assisted reproduction.

When does a sperm DNA fragmentation test happen?

A sperm DNA fragmentation test usually happens in the pre-treatment investigations stage, alongside a semen analysis and culture. Similar to a semen analysis, you must abstain from ejaculation for three to five days and then attend the clinic to provide a sample.

How long do the sperm fragmentation test results take?

The sperm DNA fragmentation results are usually back with your consultant within three weeks. We will contact you to discuss your next steps.

What are the benefits of getting a DNA fragmentation sperm test?

A sperm DNA fragmentation analysis can offer many insights, and is often undertaken alongside a sperm analysis or sperm culture to provide a full picture of male reproductive health. With in-depth knowledge about your sperm health, your doctor can help you navigate the best next steps in your fertility journey.

How much does a sperm DNA fragmentation test cost?

If you like to learn more about our prices, please refer to our price list or get in touch with our team.

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